Osteoarthritis and osteoporosis: They sound similar, they both affect your bones, and when you’ve been diagnosed with either, it can be difficult to tell them apart – or understand the relationship between the two. As both conditions impact your ability to stay comfortable, mobile and safe as you age, knowing the key differences between osteoarthritis and osteoporosis can help you make the best choices for your health, having a significant impact on your quality of life.